- Every family has rare genetic variants
- Most genetic variants are benign and do not change disease risk
- Sometimes it is not clear if a genetic variant causes disease or not
- If there is not enough evidence or inconsistent evidence about a genetic variant, it is called a variant of uncertain clinical significance (or VUS)
- Individuals with VUS should not change their medical decisions based on their VUS
The purpose of this website is to help people with VUS, identified through genetic testing, to learn more about their VUS and to assist families in finding out more about what a genetic variant means.