- Every family has rare genetic variants
- Most variants are benign and do not change disease risk
- Sometimes it is not clear if a genetic variant causes disease or not
- If there is not enough evidence or inconsistent evidence about a variant, it is called a variant of uncertain clinical significance or VUS
- Individuals with VUS should not change their medical decisions because of the VUS
This purpose of this website is to help people with a VUS identified through genetic testing learn more about their VUS and how families may help find out more about what a variant means.